Potential Anti-Aging Drug

Ibuprofen will decrease the clotting ability of your blood even more when combined with blood thinner. Generally people who take warfarin/coumadin should never take nonsteroidal anti-inflammatory drugs (NSAIDs, IE: ibuprofen, naproxen etc) because NSAIDs increase the risk of uncontrollable bleeding.  Do not take Ibuprofen when on warfarin, or any other blood thinners for that matter, unless you consult your doctor. Your doctor may allow NSAIDs over a short duration, but with a background of stomach protection eg Omeprazole, Ranitidine.

One of the most common pain-relievers could be promising in the quest for longevity, according to a new study in animals in the journal PLOS Genetics.

In the research, scientists treated yeast, worms, and fruit flies with normal doses of ibuprofen (which is a nonsteroidal anti-inflammatory drug, or NSAID, popularly known by the brand names of Advil and or Motrin). The doses were akin to what a human might take for a regular headache or a little muscle soreness.

Source: This drug could be promising in extending life (and it’s already in your medicine cabinet)

If you actually look at the study, the equivalent dose in humans for the levels they were testing was a single dose of 400mg. When they looked at humans with on a higher dose (600 mg) they found significantly higher levels that were not found to be protective in higher order organisms. In the higher order organisms, significant lower amounts were protective.

This doesn’t take into account “unhealthy” models like most humans. Even if it translated to the same 15% average gain in human cellular lifespan, there is no guarantee or even likelihood it wouldn’t be wiped out by increased cardiovascular death, renal failure, and gastrointestinal (GI) bleeds. These insect and worm models didn’t eat a typical western diet during the study 😉

But it interesting that more studies have shown that taking ibuprofen increases your risk of heart attack, and the more you take or the more often you take, the greater the risk.  Even in a healthy individual 1-2 weeks of moderate to high dose ibuprofen (600 – 1000 mg, three times a day for “moderate-high” dose. If your old or small then reduce 200 – 400 mg.) use can GI problems (which can range from heartburn like pain to life threatening GI bleeding). I don’t recommend any courses longer than 7 days (followed by that much time off before restarting if needed). It’s also rough on the kidneys and can cause kidney failure – particularly if you are not well hydrated so make sure you take doses with a big glass of water.

The older you get – the worse NSAIDs get for you, and the more prone to adverse effects you become.