‘Metabolic Switch’ Toggles Our Cells to Store or Burn Fat

It seems like cruel fate that some folks are naturally thin, while others have to work tirelessly to control their weight. But in the future, we may be able to level the playing field, because scientists have just discovered a ‘metabolic master switch’ that determines whether fat-producing adipocytes store or burn energy.

Source: ‘Metabolic Switch’ Toggles Our Cells to Store or Burn Fat

It’s a potential avenue for medication, which would be years or even decades from reality.  While it’d be interesting to get confirmation why some have more difficulty than others with loosing weight, I think ignorance is bliss so I think time is better spent dieting for actual results.

Body Fat Can Signal the Brain, Affecting Stress Response

The brain’s effect on other parts of the body has been well established. Now, a group that includes two University of Florida Health researchers has found that it’s a two-way street: Body fat can send a signal that affects the way the brain deals with stress and metabolism.

…“The big question is the nature of that signal to the brain. We need to learn how to go in and break that cycle of stress, eating and weight gain,” Herman said.

Source: Researchers: Body fat can send signals to brain, affecting stress response

Fat releases estrogen as well.  Estrogen causes increased body fat which increases estrogen which increases body fat.  They actually found treating middle-aged men with testosterone therapy helped them to reduce their belly fat inches.  Keep in mind, the belly fat was lost from caloric restriction. The body was just not in “STORE FAT” estrogen mode so the fat came off easier and was not automatically restored upon eating.

Original research: Adipocyte glucocorticoid receptors mediate fat-to-brain signaling