Sweet Drug Clears Cholesterol, Reverses Heart Disease—And Was Found by Parents

Two parents’ quest to save their twin daughters’ lives from a rare, degenerative genetic disorder may end up saving and improving the lives of millions.

Source: Sweet drug clears cholesterol, reverses heart disease—and was found by parents

From  http://stm.sciencemag.org/content/8/333/333ra50 :

Cyclodextrin is a common FDA-approved substance that is already used as a solubilizing agent to improve delivery of various drugs.

Most People Have Cholesterol All Wrong

Do you know which foods contain good cholesterol, and which contain bad cholesterol? If you think you do, ha! That’s a trick question! Cholesterol in our food doesn’t come in “good” and “bad” varieties, but cholesterol readings from blood tests do, and the two aren’t as closely connected as we used to think.

Source: Most People Have Cholesterol All Wrong

HDL is the one you want to be high; you want LDL to be low.

My doctor told me that my levels were a tad high, but the ratio mattered more.  The best part?  No cholesterol medication suggestion from the doctor.  It really does pay to eat better and look after yourself.

Related: The Dangerous Power of Health Media: 28,000 Quit Statins After Scare Documentary

What You Can Learn By Drinking Pig Spit

Something to supplant tequila?

In 2001, Ajit Varki drank a bunch of pig spit. What does drinking the extraction of pig salivary glands give you? Sialic acid, something every mammal in the world produces except humans. Why are we left out?

Source: What You Can Learn By Drinking Pig Spit

Neu5Gc has been covered before: Large Red Meat Consumption Triggers Immune Response, Leading to Cancer

Fish Oil Not So Perfect After All

Fish oil is now the third most widely used dietary supplement in the United States, after vitamins and minerals, according to a recent report from the National Institutes of Health. At least 10 percent of Americans take fish oil regularly, most believing that the omega-3 fatty acids in the supplements will protect their cardiovascular health.

But there is one big problem: The vast majority of clinical trials involving fish oil have found no evidence that it lowers the risk of heart attack and stroke.

…Dr. Stein also cautions that fish oil can be hazardous when combined with aspirin or other blood thinners. “Very frequently we find people taking aspirin or a ‘super aspirin’ and they’re taking fish oil, too, and they’re bruising very easily and having nosebleeds,” he said. “And then when we stop the fish oil, it gets better.”

Source: Fish Oil Claims Not Supported by Research

While it’s interesting that so many studies support that there’s no link between the health claims and fish oil extract, there’s only a passing mention of FDA review and support.  Nothing about if the supplement actually contains fish oil.  If other supplements are full of asparagus and lies

My stance remains firmly no-supplement.  Nothing is 100% safe, with farmed salmon getting dyed to resemble wild, or the known fraud in olive oil…  Doing the best you can is all you can hope for, and the field changes without your knowledge.

Why is Increasing My Heart Rate with Exercise Good, but Medication/Narcotics Bad?

Everything in medicine has its risks and benefits, and must be weighed.

Narcotics (opiates) do not typically increase the heart rate, but drugs like cocaine and meth do, as they cause a sympathetic surge (adrenaline rush). Regarding cocaine, it not only causes an increased heart rate but it can cause your coronary arteries (the blood vessels to your heart) to constrict (squeeze), resulting in heart attacks due to not enough blood and oxygen getting to the cardiac tissue. Additionally, cocaine has been shown to accelerate the process of atherosclerosis (plaque build-up inside arteries) which can lead to heart attacks as well. In other words, you can make your 20 year old arteries look like those of a 60 year old.  Additionally, with this surge comes an elevation in blood pressure, which can cause things like intracranial bleeding (head bleeds), aortic dissections (tears) and other not so fun things.

The temporary elevation that exercise provides is okay, to a degree, but you’re increasing your heart rate. In healthy individuals, blood pressure (BP) should increase with increasing exercise intensity, with most of that change coming in systolic BP. Diastolic BP, in healthy individuals, will stay the same or slightly increase (increases or decreases of diastolic BP of 10 mm Hg or more is criteria for terminating exercise). Lack of systolic response to increasing intensity can be a reason to stop grade exercise testing (beta blockers can affect BP responses, blunting them in testing). During steady state exercise, systolic BP will increase to a point and then plateau, but should still increase from resting levels.

Exercise does not result in the arterial constriction that we see in cocaine users. With consistent exercise, your resting heart rate will decrease as the heart molds itself and becomes more efficient. Your heart is essentially strengthened as a result of exercise, so it needs to beat less frequently.  You can see the difference in cadavers – large hearts generally indicates the person was a runner.

These are no substitute for exercise as the myriad of elements that constitute exercise involve multiple other hormones and bio-chemicals released and involve other processes such as peripheral vasodilation and visceral vasoconstriction.  Using these medications to “exercise” your heart will not improve your conditioning and in fact, if used over a long period of time, increase your mortality.

An increase in heart rate due to anxiety is a trigger from your sympathetic nervous system. This is the “fight or flight” side of the nervous system that can be triggered from stress, pain, anxiety, etc. The triggering of this reaction also causes an increase in BP, among other things.

If your BP and heart rate are frequently increased from this, it can lead to an increased risk for heart disease, heart failure, stroke, and atherosclerosis. Don’t worry about it too much, though. There are a couple of things that you can do to counteract these things:

  1. Exercise
  2. Watch sodium intake – sodium makes you store less water on your body causing the total amount of blood to decrease, therefore lowering blood pressure.

Fun fact: During the time you exercise you are at much greater risk of sudden cardiac death (heart stopping), myocardial infarction (MI, AKA heart attack), arrhythmia (abnormal rhythms of the heart), and stroke. But the time after you exercise, you get a decrease in your overall cardiovascular mortality (death) and morbidity (sickness) that more than compensates for the increased mortality of exercise.

TLDR: Narcotics are not the issue, but drugs like cocaine will make your heart weaker along with all the other bad stuff drugs can do.

Study: Large Red Meat Consumption Triggers Immune Response, Leading to Cancer

It should be made clear that the research appears reputable. The research does not rely upon statistical analysis that can be potentially biased. It’s about the presence or absence of genetic mutations in different species, making the results extremely robust.  However, in this study the high Neu5Gc diet was 0.25 mg of Neu5Gc per gram of food. For comparison their estimated range of Neu5Gc content in beef is 0.023-0.231 mg per gram.  Effectively the mice were fed ~1,000 times more Neu5Gc in their food than what is found in a steak.  And the mice could only eat this pellet, whereas humans don’t only eat steak.

Red meat has been linked to cancer for decades, with research suggesting that eating large amounts of pork, beef or lamb raises the risk of deadly tumours. But for the first time scientists think they know what is causing the effect. The body, it seems, views red meat as a foreign invader and sparks a toxic immune response.

Source: Red meat triggers toxic immune reaction which causes cancer, scientists find

Red meat contains Neu5Gc. Pork has more Neu5Gc than beef, and dairy has it too. Fish contains trace amounts, and poultry has none.  Cooking didn’t have a significant effect on the Neu5Gc content – cooking reduced water weight, and therefore increased the µg/g value.  Here’s the chart from the paper:

Neu5Gc Content and Percentage of Various Food Groups

Neu5Gc Content and Percentage of Various Food Groups

When our ancestors evolutionary diverged from chimpanzees, we developed a mutation in an enzyme known as CMAH. CMAH catalyzes the addition of a hydroxyl group to sialic acid (NeuNAc) to produce Neu5Gc (NeuNAc w/ added -OH). One of the things that makes you uniquely human compared to almost all other mammals are the patterns of carbohydrates that cover the surface of your cells.  What makes you uniquely human is the striking lack of Neu5Gc on your cells compared to almost all other mammals.

Mutation of the CMAH enzymatic pathway may have promoted developmental brain complexity. This supports the view that human ancestors ate a primarily vegan diet.  With little rare meat consumption to result in accelerated aging, the effects of this reduced fitness was outweighed by increased brain complexity that may have provided a survival advantage for mutants.

Glycoscience is a new branch of science that will help us get closer to understanding the human body in the finest details. If this research is confirmed to be true, it will have great implications on how to make consumption of red meat safe (genetic modification?) and could shed more light on how the body prevents cancer from spreading out of control (not everyone dies from cancer).