Scientists Create Injectable Foam To Repair Degenerating Bones

Researchers in France have developed a self-setting foam that can repair defects in bones and assist growth. Eventually, this advanced biomaterial could be used to quickly regenerate bone growth and treat degenerative diseases such as osteoporosis.

Source: Scientists Create Injectable Foam To Repair Degenerating Bones

The first thought that popped into my head was: “Does this mean longer space time for astronauts?”  They go up, experience bone loss, come down get treated with this foam, recover, and then go back up…

 

We’re One Step Closer to Being Able to Regrow a Lost Tooth

We’re one step closer to being able to regrow a lost tooth, thanks to a new study showing it’s possible to grow multiple teeth from a single root. These teeth can then be implanted to become fully functional. Thus far it has only been tested in rats, but it could lead to a potential revolution in human dental care.

Source: We’re One Step Closer to Being Able to Regrow a Lost Tooth

Why this over an implant?  Dentures are notorious for not staying seated, and the fit might not be that great to begin with.  A natural tooth would discolour, while implants are less likely.  Getting “full functionality” also means the ability to have another root canal 😉

Chicken Broth Comes Out Better on the Stovetop or Pressure Cooker, Not the Slow Cooker

…there are also times when I’m in a hurry and I want that great chicken stock NOW. Likewise, there are days when I need to step out for a while and I don’t want to leave an unattended pot simmering on the stovetop. This is when I think about pulling out the pressure cooker or the slow cooker. But how do the results compare?

Source: Ask the Food Lab: Can I Make Stock in a Pressure Cooker or Slow Cooker?

Don’t forget that you can alter the body by adding gelatin.

  1. The author set his slow cooker on low. He should have made a fourth batch with it set on high.
  2. Different slow cookers reach different temperatures. Mine reaches a good simmer on low and a boil on high.
  3. He doesn’t say whether he started with cooked or raw chicken scraps. A couple of the best batches of stock I’ve ever made were from the carcass of my Thanksgiving turkey done in a slow cooker which I started right after the meal an let simmer all night. I wonder if using cooked bones makes a difference.

This Luxurious Yarn Is Made From Bones, Ligaments and Tendons

It’s people!  They really should name the product “soylent wool” 😀

Wendelin Stark would like a new sweater. It’s cold in Zürich, where he lives, so he’d like a really warm one. Preferably one as cozy as cashmere.

Before long, Stark may be wearing one of his own invention, crafted with an ultra-soft wool-like yarn spun from all the stuff that’s left after an animal’s been slaughtered and processed. His team at the Functional Materials Laboratory at ETH Zürich, where he’s a professor, has spent four years creating such a fabric, and recently created a working prototype—of a mitten.

Source: Luxury Wool Made From … Leftover Animal Parts?

My preferred use for animal by-products is petroleum production.  There was news years ago about someone who’d pioneered a contraption to produce petroleum/oil from chicken carcasses, wanting to employ them near chicken farms.  I doubt it would be enough volume to fuel vehicles, but given the hurdles that the gelatin wool still has to address – petroleum production for textiles that already work would be a better use of resources to me.  We are more dependent on petroleum products than we’d like to admit.

Sunlight and Body Heat Make Vitamin D Inside Your Skin

Many people don’t get enough vitamin D in their food. They still get enough vitamin D, because ultraviolet radiation creates it—usually.

Source: Sunlight and Body Heat Make Vitamin D Inside Your Skin

If you’re as fair-skinned as the average northern European, you only need about 20 minutes per day.  All you have to show is an area of skin about the size of your face.

Without vitamin D from sunlight exposure, lactose assists with the use of calcium. So, cultures with easy access to leafy greens plus sunlight or fish, calcium is taken care of and milk has no advantage. Cultures without access to leafy greens, sunlight or seafood need dairy either as a source of calcium, lactose, or both.  You can read more about it in a previous post.

How Much Radiation Does the Human Body Emit?

How much of a dose of radiation do you get by snuggling up against your significant other for a year? Unless they’re glowing green, it’s a small dose, but it’s not nothing. We’ll tell you how much radiation you, and the people around you, emit.

Source: How Much Radiation Does the Human Body Emit?

Remember:

Lots of everyday stuff is radioactive:

  • bricks
  • kitty litter
  • granite

Your Own Body Smuggles In This Radioactive Particle

Strontium-90 is not good news. It emits ionizing radiation, which means you want to keep it out of our body. Unfortunately, your body has other ideas. The body’s own mechanisms welcome this isotope in, and store it away.

Source: Your Own Body Smuggles In This Radioactive Particle

Strontium isn’t the only calcium mimic. Strontium-89 has been used to treat cancer spread to bones, but has largely been replaced by Samarium-153 which is less toxic. These are most commonly used in prostate cancer, but Radium-223 has superseded both in that disease as it is more effective and probably safer.

8 Things That Happen When You Finally Stop Drinking Diet Soda

You’ve decided to give up diet soda—good idea! Maybe you weren’t hitting your weight-loss goals or couldn’t stomach that long list of ingredients anymore. Or perhaps you heard one too many times that it’s just not good for you.

Whatever the reason, eliminating diet soda from your diet will improve your health from head to toe. Research on diet soda is still in its infancy, but there’s enough out there to identify what you can look forward to when you put down the can and cool down with an unsweetened iced tea instead.

Source: 8 Things That Happen When You Finally Stop Drinking Diet Soda

Sorry, but soda/pop is one place I will not consider the diet alternative.  Simply due to taste – most just prompted me to drink water instead (for the best anyway, but not for Big Soda/Pop).

The aspect of weight loss because of coming off diet soda/pop isn’t that surprising.  It’s often suggested that we consume more because we’re under the impression the food/beverage is healthier so we can consume more. As the joke goes: I’ll have the extra large burger, extra large fries, and …a diet soft drink.

Why Don’t I Look Like My Goal Physique Yet?

There are only so many things you can control in life, and your genetics isn’t one of them. Aside from hitting the gym and plastic surgery, you have little say over how your appearance turns out—and even then, you may have less control than you think.

Source: Why Don’t I Look Like My Goal Physique Yet?

Do it for your health, not your looks.  You can shoot for both, but the former is more important.

Study: Cannabinoid CBD “Enhances Bone Fracture Healing” in Rat Model

Cannabinoid ligands regulate bone mass, but skeletal effects of cannabis (marijuana and hashish) have not been reported. Bone fractures are highly prevalent, involving prolonged immobilization and discomfort. Here we report that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enhances the biomechanical properties of healing rat mid-femoral fractures.

Source: Cannabidiol, a Major Non-Psychotrophic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.

Bone Fracture Healing 101

Basically, after a fracture you get an initial cartilaginous callus that forms across the gap. That callus then mineralizes, and is replaced by a bony callus, which is remodeled into mature bone. It is fairly well known that there are cannabinoid receptors that are involved in picking up the endocannibinoids (the cannabinoid molecules that your body produces) and have an effect in bone fracture healing.

CBD 101

  1. Cannabidiol/CBD is a key component in cannabis
  2. CBD is non-psychoactive, and the active compound in medical marijuana
  3. CBD reduces the negative effects of THC
  4. CBD is illegal, classified as a Schedule I drug in the United States and a Schedule II drug in Canada

What this Paper Did

They performed three experiments.

The first experiment was testing the effects of administering:

  • just THC
  • just CBD
  • or a control

…on structural and mechanical properties of the fracture healing. These rats received femoral fractures following having a pin put in place to stabilize the fracture. They then began receiving 5 mg/kg/day doses of THC, CBD, or just the delivery solution. They then sacrificed the rats at various time points (2, 4, 6, and 8 weeks), and examined the fracture using microcomputed tomography and mechanical testing. At 4 weeks, it looks like this: figure, caption, where you can see callus formation. They found that the callus size in rats administered either THC or CBD was ~26% smaller than the control rats at the 4 week time point, but this was not present in the 6 or 8 week time points. This can be seen in this figure, caption. They then performed mechanical testing on the bone and found an enhancement of ~35% maximal force and ~50% work to failure in the CBD treated bones at the 8 week time point, but not in THC or control bones. The ultimate displacement at failure was not increased (how much the bone bends before it breaks), which indicates that the improvement in work to failure (basically, how tough the bone is) was due to strength improvements.

In the second experiment, they were testing the effect of delivery a mixture of equal amounts of THC and CBD on the mechanical properties of the callus because that is about the ratio recommended in most therapeutic cannabis. In this experiment, they only looked at the mechanical properties. The results can be seen here: figure, caption, but basically they found that the addition of THC slightly improved the maximal force, but eliminated the increased work to failure at 8 weeks. There were improvements at 6 weeks. I personally have problems with this comparison, because they were comparing the results from this 2nd experiment directly to the prior experiment, rather than adding additional groups to the 2nd experiment. It may be valid, but if there were odd changes they didn’t realize between experiments it could have an effect here.

Next, they wanted to assess the effects of THC and CBD on bone material properties so they could figure out what the mechanism of action of the CBD fracture healing effect. They analyzed the material density of the mineralized matrix, and found no differences between the treatment groups (see figure, caption), and found that there was no change in the actual mineralization. That means the effects of the CBD were coming from changes to the organic component of bone.

To show this, they cultured osteoblasts (the cells that produce bone), and administered CBD to the osteoblasts. They looked at the expression of PLOD1, which is an gene that creates an enzyme that plays a role in collagen crosslinking. The results are here: figure, caption. Basically, they found that there was an increase in expression for CBD at moderate levels, but decreased at higher concentrations (fairly expected). THC showed an increase at high levels of the PLOD2 gene, but didn’t show an effect on PLOD1.

They then performed spectroscopy on the callus tissue of the specimens from the first 2 experiments, and found the degree of collagen crosslinking was greater in samples that had been treated with CBD alone, but did not see any increase in either THC, or CBD+THC. I can’t post the figures with the data, because they appear to have forgotten to include them (I assume the publishers will catch this prior to full publication).

Summary

They found that delivery of CBD alone promoted improvement in some of the mechanical properties in fracture healing. The actual amount is a bit hard to tell, but it was enough to be statistically significant (P<0.05) using a very nonconservative test (Fisher’s LSD, which is commonly used, and in my opinion, overused). Their results also indicated that the impact comes during the late stages of bone healing (I would be curious to see a test with injections starting at 5 weeks or so), and they believe it may be due to increased collagen crosslinking. Further research is needed because this is very preliminary. There was no evidence that smoking cannabis (or vaping, or eating) would provide the benefits that they saw here, because they were testing using injections under the skin.

TLDR

Cannabinoid, but not THC provides some improvement in mechanical properties during fracture healing, maybe due to increased collagen crosslinking. More research is necessary. This does not recommend smoking cannabis.

Supposition

Maybe this could be used to stave off osteoporosis?