Body Fat Can Signal the Brain, Affecting Stress Response

The brain’s effect on other parts of the body has been well established. Now, a group that includes two University of Florida Health researchers has found that it’s a two-way street: Body fat can send a signal that affects the way the brain deals with stress and metabolism.

…“The big question is the nature of that signal to the brain. We need to learn how to go in and break that cycle of stress, eating and weight gain,” Herman said.

Source: Researchers: Body fat can send signals to brain, affecting stress response

Fat releases estrogen as well.  Estrogen causes increased body fat which increases estrogen which increases body fat.  They actually found treating middle-aged men with testosterone therapy helped them to reduce their belly fat inches.  Keep in mind, the belly fat was lost from caloric restriction. The body was just not in “STORE FAT” estrogen mode so the fat came off easier and was not automatically restored upon eating.

Original research: Adipocyte glucocorticoid receptors mediate fat-to-brain signaling