Study: Bovine Milk Exosomes Contain microRNA and mRNA, and are Taken up by Human Macrophages

We reported previously that microRNA (miRNA) are present in whey fractions of human breast milk, bovine milk, and rat milk.

…In the current study, we used bovine raw milk and total RNA purified from exosomes (prepared by ultracentrifugation) and ultracentrifuged supernatants, and analyzed them using miRNA and mRNA microarrays to clarify which miRNA and mRNA species are present in exosomes, and which species exist in other forms.

…These results suggest that bovine milk exosomes might have effects in human cells by containing RNA.

Source: Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages

Exocytosis is a normal cellular function, and is one way cells can communicate with each other or provide additional benefits to another. The picture in the wikipedia image shows exocytosis occurring between two neurons, but the process is by no means exclusive to this cell type. Basically, cells can form exosomes, or membrane-bound vesicles which are released from the cell. These can contain proteins, DNA, RNA, you name it.

It’s been known for a while that human milk also contains species of mRNA (messenger RNA) and miRNA (micro RNA). This study essentially says they’re also found in bovine milk. Moreover, they’re primarily located within exosomes when the milk is fractionated. Some of the miRNAs they found in the top 10 are actually shared in both human and pig milk and are predicted to regulate both carbohydrate and lipid metabolism. There are also species-specific miRNAs present in the exosomes, whose function is unknown (as is the majority of the RNA found).

They predict, due to the stability and acid-resistant characteristics of these RNA species, that they may serve a biological function, but they don’t know for sure. They found that a human macrophage-like cell line (an innate immune cell type) can take up these exosomes, but they don’t know if other cell types can as well. So basically, cow milk has all these RNA-containing exosomes floating around in it (much like human milk), and some of them are taken up by our cells. Biological functions still unknown.

TLDR

Cells can release tiny packets of genetic material which can be taken up by other cells. The authors of this study found that cow milk contains these packets of material. In fact, some of this material is also found in other species, like humans and pigs. This material is super resilient, and so may serve some function, but we don’t know what! Also, some of our immune cells can take up these packets of material. We still don’t know what it does though.

This Experiment First Cracked the Genetic Code—But Most People Have Never Heard of It

One of the most important experiments in the world manages to fly under most people’s radar. After years of patient experimental work, two scientists managed to figure out how one code in DNA translated into an actual, physical protein.

Source: This Experiment First Cracked the Genetic Code—But Most People Have Never Heard of It

It’s nice to see a headline on the net not confusing the genetic code with the genetic sequence. Only the latter is something akin to the source code of computer science, whereas the former governs how genetic information is translated into proteins.

One Step Closer to Immortality, Study Safely Extends Telomeres

Researchers delivered a modified RNA that encodes a telomere-extending protein to cultured human cells. Cell proliferation capacity was dramatically increased, yielding large numbers of cells for study.

…The newly developed technique has an important advantage over other potential methods: It’s temporary. The modified RNA is designed to reduce the cell’s immune response to the treatment and allow the TERT-encoding message to stick around a bit longer than an unmodified message would. But it dissipates and is gone within about 48 hours. After that time, the newly lengthened telomeres begin to progressively shorten again with each cell division.

Source: Telomere extension turns back aging clock in cultured human cells, study finds

This is very important because the big danger in telomere lengthening is the immortalization of cells, meaning cancer.  Telomere lengthening is old hat but the transcience factor is huge for anti-cancer and immune response.  Reason being that transient telomere lengthening allows for a rejuvenation of cells without tumorigenesis. Safely reverting the senescence response is absolutely crucial to ending aging.  However if this telomere lengthening increases lifespan, then there’s more time in which you may develop cancer or other illness from a mutation.  Does this technique increase the chances of cancer above what you’d expect solely from having lived for a longer duration?

This could be the key to making it economical and practical to grow beef or chicken muscle in a manufacturing facility…  Vegetarians, how do you feel about sustainable lab-cultured meat?

That said, I’m quite worried about the impact to society and environment.  Competition for resources and work will increase as turnover because of retirement is less likely to happen.  And it’d be compounded by the continuing advancements in automated technology like Artificial Intelligence (AI) and robots.  Also:

You're just not fast food chain material

SMBC saw this coming