The First Real “Magic Bullet” in Medicine Was Arsenic

There wasn’t much to be done about syphilis for most of its history. It was a horrible, slow way to die and the only way to ward off the most acute attacks was mercury—until a dye and a poison provided the inspiration for an effective treatment.

Source: The First Real “Magic Bullet” in Medicine Was Arsenic

Arsenic is still a silver bullet today. It’s used to cure Acute Promyelocytic Leukemia. Cure, not treat; and APML used to be a death sentence.

Century-old Drug Reverses Autism-like Symptoms in Fragile X Mouse Model

Researchers previously reported that a drug used for almost a century to treat trypanosomiasis, or sleeping sickness, reversed environmental autism-like symptoms in mice. Now, a new study suggests that a genetic form of autism-like symptoms in mice are also corrected with the drug, even when treatment was started in young adult mice.

Source: Century-old drug reverses autism-like symptoms in fragile X mouse model

  1. Suramin is not a drug that can be used for more than a few months without a risk of toxicity in humans.
  2. The effect is not permanent. The experimental mice’s autistic behaviours come back once the suramin has disappeared from their bodies. But these are interesting results.

For a very long time now, scientists have viewed Autism Spectrum Disorder (ASD) as a cellular/genetic disorder and relatively recently researchers are now appreciating neuroimmunology as a whole. However, neuroimmunology is still a difficult field to work in, for a variety of reasons, so there is still a lot of potential in the near and distant future. The genetic, molecular, cellular, systems-level perturbations that lead to ASD do in fact underlie every mental disorder. The two are not mutually exclusive and in fact are dependent on one another.

For those who have ASD, or know someone who does, there’s research to suggest it’s worth considering ketogenic diet.  I’d first heard of the ketogenic diet being good for epileptics.