In Rodents Fed High-Fat Diets, Gut Microbes Boost Hunger, Trigger Obesity

After several hints that gut microbes may be key players in the obesity epidemic, a new study provides a mechanistic explanation of how the intestinal inhabitants directly induce hunger, insulin resistance, and ultimately obesity in rodents.

Source: In rodents fed high-fat diets, gut microbes boost hunger, trigger obesity

The percentage of fat in our diets (since the early 80s) has gone down, but protein stayed the same, and carbs have gone up to pick up the slack.

Scientists Find Cure For Type 2 Diabetes in Rodents, Don’t Know How it Works

The cure for type 2 diabetes may be all in your head, a new study in rats and mice suggests.

With a single shot to the brain, researchers can rid rodents of all symptoms of the disease for months. The injection, a relatively low dose of a tissue growth factor protein called fibroblast growth factor 1 (FGF1), appears to reset powerful neural networks that can control the amount of sugar in the blood.

Source: Scientists find cure for type 2 diabetes in rodents, don’t know how it works

Oh sure. When some guy in a lab coat injects something into a rodent’s brain it’s call “science”. When try to inject something into a bear’s arm I get banned from the zoo and arrested for having heroin.

Study: Former Biggest Loser Contestants’ Metabolisms Are Wrecked, Leading to Weight Gain

Contestants lost hundreds of pounds during Season 8, but gained them back. A study of their struggles helps explain why so many people fail to keep off the weight they lose.

Source: After ‘The Biggest Loser,’ Their Bodies Fought to Regain Weight

Two individuals, each of the same size/weight, but one who had lost a substantial amount of weight to arrive there, end up with significantly different resting metabolisms, such that it becomes impractical to maintain the weight loss.  The alternative for those people is to devote substantial amounts of time to exercise to maintain caloric burn rates that counter their abnormally low metabolisms.  That’s part of the lifestyle change – crash/fad diets do not work for the long term.

Standing Desks Are No Replacement For a Workout

Planting your behind in a seat for hours at a time has been squarely linked to an increase in health problems, from shorter lifespans to a slew of diseases, including cancer. Concerned office workers have leapt to standing desks as healthier alternatives. But prolonged sitting may be getting a bum rap, a new study suggests.

Source: Standing desks are no replacement for a workout

The moral of the story is still this: go out and get some exercise.

No gym membership needed. Go out and run. Or walk at first if you can’t run. Or try cycling. Or try rowing. Or swimming. Can’t swim? Even better- you’ll go on a great journey just learning how to swim crawl correctly.

What – winters are bad where you live? Cross country skiing.   Endurance exercise has the power to change your life.

Nearly Half a Billion People Now Have Diabetes

Tomorrow is World Health Day, and to mark the occasion, the World Health Organization has released its first ever global report on diabetes. The results are frightening.

Source: Nearly Half a Billion People Now Have Diabetes

I have a friend who is a podiatrist; you’d be amazed the stories I’ve heard of folks with gangrene or other lesions that they’ve had for months and allow to go untreated.

People eating crap (*consistently*) and not even caring a little about their health…I don’t get it.

I’d type more but my lunch pizza is getting cold.

Parents’ Bad Diets May Mess With Genes, Boost Kids’ Risk of Obesity, Diabetes

A crummy diet can obviously have a lasting impact on the waistline—but for parents, it may also have a lasting impact on DNA and the family line, a new study suggests.

Source: Parents’ bad diets may mess with genes, boost kids’ risk of obesity, diabetes

It’d be interesting to test if the epigenetic changes are permanent, or if they can be reversed by the fat mouse loosing weight.

This Video Debunks 10 Misconceptions About Your Favorite Beverages

To be clear – tap water is more heavily regulated than bottled water, and the presenter makes sure to say that the actual water quality depends on location (obviously Flint and WV are outliers).

Liver hormone may be the off-switch for sweet-tooth, cocktail cravings

Gimmicky diets, flavor fakery, and sham sweets all try to bamboozle the brain out of wanting sugary treats and calorie-packed happy hour drinks. But scientists may have found an all-natural way to simply switch off those corrupting cravings.

Source: Liver hormone may be the off-switch for sweet-tooth, cocktail cravings

I am always nervous about hormone treatments, as we usually do not know all the side effects of the hormone treatments, as the body is a series of complex chemical interactions driven in part by hormones.  I am even more nervous about chemical treatments than hormone treatments, as they are not usually natural to the body and can throw things out of whack leaving the body no natural way to overcome the chemical imbalance.  So I am cautiously optimistic that this is a better treatment path than existing medicines, as the hormone occurs naturally in the body, appears to be directly involved in doing what they want it to do already, and hopefully the body has some built in methods to handle additional amounts of the hormone with fewer serious side effects.

High Intensity Interval Training: Good for Pre-Diabetic and Type 2 Diabetics

…in mice.  That said, there’s an increasing number of studies on high intensity interval training (HIIT) showing good things.

Highlights

  • High-intensity interval training (HIIT) improves exercise capacity and whole-body glucose homeostasis.
  • HIIT enhances liver and adipose tissue insulin sensitivity independent of body weight and adiposity.
  • HIIT does not change adipose tissue cell size, macrophage infiltration, inflammation and liver lipid content.
  • HIIT exercise training improves insulin sensitivity independently of the AMPK-ACC signaling pathway.

Source: High intensity interval training improves liver and adipose tissue insulin sensitivity

If you are diabetic or nearing it, this article means that this kind of training would be greatly beneficial to you in particular.  HIIT can be adapted to the individual’s level of fitness just like any type of training regimen. It’s all about monitoring the heart rate really and adjusting the workout accordingly.  Weight training also has the same effect on reducing insulin resistance, and is more effective than endurance training.

Many people internalize type 2 diabetes as having a lack of insulin; I think it better described as having an overabundance of insulin resistance.

New Diabetes Cases Finally on the Decline

After decades of relentless rise, the number of new cases of diabetes in the United States has finally started to decline.

Source: New Diabetes Cases, at Long Last, Begin to Fall in the United States

While minorities have higher rates of diabetes than non-Hispanic whites in general:

…I think, in absolute numbers, whites still make up the majority of diabetes cases.

The higher rates of diabetes in minorities is a complicated issue. Genetics may play some part in it, but the bulk of the risk comes from socioeconomic factors. There are such things as urban food deserts where a healthy diet is not easily available. Take the case of New York City. Here’s a map of veggie intake, supermarket availablity, and diabetes rates. You may notice that these neighborhoods correspond closely with low-income, minority populated neighborhoods. Speaking from personal experience living in some of these areas, fried and fast foods are readily available. Fresh fruits and veggies? Not as much.